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Nyrada Inc. Marks Milestone with Successful Phase I Clinical Trial of Xolatryp

Aug 06, 2025

Nyrada Inc. (ASX: NYR), a clinical-stage biotechnology firm, has successfully completed its first-in-human Phase I trial of Xolatryp™, a pioneering small-molecule therapy for heart and brain protection. Across six cohorts, 48 healthy volunteers participated, and the Safety Review Committee confirmed the absence of serious adverse events or dose-limiting toxicities, affirming Xolatryp™’s favorable safety profile. The therapy demonstrated predictable pharmacokinetics, with consistent clearance and tolerability during both 3-hour and 6-hour infusions.

With data cleaning underway and topline results expected in the September 2025 quarter, the company is preparing to advance to a Phase IIa trial in early 2026. This next stage will evaluate safety and exploratory efficacy in patients suffering from acute myocardial infarction (STEMI) undergoing PCI. Preclinical studies revealed robust cardioprotective and neuroprotective effects, highlighting Xolatryp™’s potential to safeguard irreplaceable heart and brain tissue, reduce injury biomarkers, and lower the risk of life-threatening arrhythmias.

 

 

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